PMID: 15561897

Bryan J, Vila-Carriles WH, Zhao G, Babenko AP, Aguilar-Bryan L
Toward linking structure with function in ATP-sensitive K+ channels.
Diabetes. 2004 Dec;53 Suppl 3:S104-12., [PubMed]
Sentences
No. Mutations Sentence Comment
132 ABCC8 p.Ser1237Tyr
X
ABCC8 p.Ser1237Tyr 15561897:132:16
status: NEW
view ABCC8 p.Ser1237Tyr details
 Substitution of Ser1237 with Tyr, the analogous residue in SUR2, reduced the apparent affinity of SUR1 for tolbutamide and glibenclamide (82). Login to comment 146 ABCC8 p.Trp232Ala
X
ABCC8 p.Trp232Ala 15561897:146:16
status: NEW
view ABCC8 p.Trp232Ala details
 Substitution of Trp232 with alanine results in loss of affinity labeling, whereas replacement with cysteine retains labeling. Login to comment 162 ABCC8 p.Trp232Ala
X
ABCC8 p.Trp232Ala 15561897:162:78
status: NEW
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ABCC8 p.Tyr230Ala
X
ABCC8 p.Tyr230Ala 15561897:162:44
status: NEW
view ABCC8 p.Tyr230Ala details
ABCC8 p.Tyr230Ala
X
ABCC8 p.Tyr230Ala 15561897:162:55
status: NEW
view ABCC8 p.Tyr230Ala details
ABCC8 p.Trp231Ala
X
ABCC8 p.Trp231Ala 15561897:162:67
status: NEW
view ABCC8 p.Trp231Ala details
 Results for the wild-type (WT) control, the Tyr230Ala (Y230A), and Trp231Ala (W232A) substitutions are shown. Login to comment