PMID: 15466394

Casas C, Sergeant N, Itier JM, Blanchard V, Wirths O, van der Kolk N, Vingtdeux V, van de Steeg E, Ret G, Canton T, Drobecq H, Clark A, Bonici B, Delacourte A, Benavides J, Schmitz C, Tremp G, Bayer TA, Benoit P, Pradier L
Massive CA1/2 neuronal loss with intraneuronal and N-terminal truncated Abeta42 accumulation in a novel Alzheimer transgenic model.
Am J Pathol. 2004 Oct;165(4):1289-300., [PubMed]
Sentences
No. Mutations Sentence Comment
1 ABCC8 p.Met233Thr
X
ABCC8 p.Met233Thr 15466394:1:224
status: NEW
view ABCC8 p.Met233Thr details
 Here we present a novel transgenic mouse model, APPSL PS1KI that closely mimics the development of AD-related neuropathological features including a significant hippocampal neuronal loss. This transgenic mouse model carries M233T/L235P knocked-in mutations in presenilin-1 and overexpresses mutated human beta-amyloid (Abeta) precursor protein. Login to comment