ABCMdb

PMID: 15357563

Wahab AA, Janahi IA, Marafia MM, El-Shafie S
Microbiological identification in cystic fibrosis patients with CFTR I1234V mutation.
J Trop Pediatr. 2004 Aug;50(4):229-33., [PubMed]

Sentences

No. Mutations Sentence Comment

6 ABCC7 p.Ile1234Val All the patients were homozygous for the I1234V mutation of CFTR gene in exon 19. Login to comment 7 ABCC7 p.Ile1234Val They were seen every 10-12 weeks in the paediatric outpatient CF clinic and additionally in acute situations. At each visit, or hospital admission the height and weight Journal of Tropical Pediatrics, Vol. 50, No. 4  Oxford University Press 2004; all rights reserved 229 Microbiological Identification in Cystic Fibrosis Patients with CFTR I1234V Mutation by A. Abdul Wahab,a I. A. Janahi,a M. M. Marafia,a and S. El-Shafieb Departments of a Pediatrics and b Microbiology, Hamad Medical Corporation, Doha, Qatar Summary Recurrent and chronic bacterial pulmonary infection is the major cause of morbidity and mortality in cystic fibrosis (CF). Login to comment 47 ABCC7 p.Ile1234Val A. ABDUL WAHAB ET AL. 230 Journal of Tropical Pediatrics Vol. 50, No. 4 TABLE 1 Data concerning isolation of organisms from patient with CF mutation I1234V (n = 36) Total H. influenza 32 S. aureus 28 Pseudomonas (mucoid) 9 Pseudomonas (non-mucoid) 9 S. maltophilia 2 Candida species 9 A. baumanni 3 A. xylosoxidans 2 Streptococcus pyogenes 5 Streptococcus pneumoniae 2 Streptococcus agalactiae Gr B 1 Streptococcus Group C 1 Mycobacterium avium intracellulare 2 M. abscessus 2 Campylobacter 1 Proteus mirabilis 1 It was noted that those with pancreatic insufficiency had higher rates of persistent pulmonary infection and more frequent hospitalization for acute respiratory exacerbation. Login to comment 53 ABCC7 p.Ile1234Val Discussion This study gives details of the microbiological spectrum of lower airway cultures in a large cohort of CF patients with a similar CFTR mutation I1234V. Login to comment 59 ABCC7 p.Ile1234Val Data collected in a 1998 multicentre study of CF patients A. ABDUL WAHAB ET AL. Journal of Tropical Pediatrics Vol. 50, No. 4 231 TABLE 2 Data concerning isolation of organisms from patient with CF mutation I1234V (n = 36) in different age groups Age groups --------------------- < 9 years > 9 years Count (%) Count (%) Total H. influenza 9 (28.1) 23 (71.9) 32 S. aureus 11 (39.3) 17 (60.7) 28 Pseudomonas (mucoid) 1 (11.1) 8 (88.9) 9 Pseudomonas (non-mucoid) 2 (22.2) 7 (77.8) 9 S. maltophilia 2 (100). Login to comment