PMID: 15266017

Xu D, Kang H, Fisher M, Juliano RL
Strategies for inhibition of MDR1 gene expression.
Mol Pharmacol. 2004 Aug;66(2):268-75., [PubMed]
Sentences
No. Mutations Sentence Comment
158 ABCB1 p.Lys25Phe
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ABCB1 p.Lys25Phe 15266017:158:110
status: NEW
view ABCB1 p.Lys25Phe details
 Thus, we used a stable subline of NCI/ADR-RES that displayed ponasterone-regulated expression of a repressor (K25F) targeted to the MDR1 promoter. Login to comment 159 ABCB1 p.Lys25Phe
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ABCB1 p.Lys25Phe 15266017:159:37
status: NEW
view ABCB1 p.Lys25Phe details
 As seen in Fig. 3D, induction of the K25F-designed repressor also caused a reduction of approximately 1 log in cell surface P-glycoprotein levels. Login to comment