ABCMdb

PMID: 15246976

Salinas DB, Pedemonte N, Muanprasat C, Finkbeiner WF, Nielson DW, Verkman AS
CFTR involvement in nasal potential differences in mice and pigs studied using a thiazolidinone CFTR inhibitor.
Am J Physiol Lung Cell Mol Physiol. 2004 Nov;287(5):L936-43. Epub 2004 Jul 9., [PubMed]

Sentences

No. Mutations Sentence Comment

53 ABCC7 p.Gly551Asp Wild-type mice and CF mice (homozygous ‚F508 or G551D) were studied. Login to comment 55 ABCC7 p.Gly551Asp Heterozygous mice were bred to generate homozygous mutant ‚F508 or G551D mutant mice. Login to comment 150 ABCC7 p.Gly551Asp Inset: PD measurement done on a cystic fibrosis (CF; G551D mutant) mouse. Login to comment 151 ABCC7 p.Gly551Asp Data are representative of studies on 19 wild-type mice (forskolin protocol), 11 wild-type mice (forskolin/genistein protocol), and 9 CF mice (6 G551D, 3 ‚F508). Login to comment 216 ABCC7 p.Gly551Asp ABCC7 p.Gly551Asp However, this conclusion must be reconciled with the observation here and from several laboratories that the low-Cl- induced hyperpolarization is absent in CF mice (CFTR null or ‚F508 or G551D) (4, 14). Login to comment