PMID: 15243210

Caslake MJ, Packard CJ
Phenotypes, genotypes and response to statin therapy.
Curr Opin Lipidol. 2004 Aug;15(4):387-92., [PubMed]
Sentences
No. Mutations Sentence Comment
7 ABCG8 p.Asp19His
X
ABCG8 p.Asp19His 15243210:7:129
status: VERIFIED
view ABCG8 p.Asp19His details
 Polymorphism in the promoter for the ABCG8 gene has been linked to variations in response to statins; individuals with the rarer D19H genotype exhibit a greater reduction in LDL-cholesterol. Login to comment 101 ABCG8 p.Asp19His
X
ABCG8 p.Asp19His 15243210:101:16
status: VERIFIED
view ABCG8 p.Asp19His details
 Carriers of the D19H variant in the ABCG8 gene exhibited greater percentage reductions in LDL-cholesterol on atorvastatin (39.7 versus 36.2%, P = 0.036) and lower achieved levels than those with the more common allele [44]. Login to comment