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PMID: 15218066
Prost AL, Bloc A, Hussy N, Derand R, Vivaudou M
Zinc is both an intracellular and extracellular regulator of KATP channel function.
J Physiol. 2004 Aug 15;559(Pt 1):157-67. Epub 2004 Jun 24.,
[PubMed]
Sentences
No.
Mutations
Sentence
Comment
162
ABCC8 p.Lys719Met
X
ABCC8 p.Lys719Met 15218066:162:220
status:
NEW
view ABCC8 p.Lys719Met details
KATP channels with impaired nucleotide binding domains are still activated by intracellular Zn2+ Channel activity was measured at -30 mV in inside-out patches excised from Xenopus oocytes coinjected with Kir6.2 and SUR1(
K719M
,K1385M) or SUR2A(D832N,D1469N).
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163
ABCC8 p.Lys719Met
X
ABCC8 p.Lys719Met 15218066:163:41
status:
NEW
view ABCC8 p.Lys719Met details
A, activation by 20 µM Zn2+ of SUR1(
K719M
,K1385M)/Kir6.2 channels. B, average currents in 100 µM ATP measured before or during application of 20 µM Zn2+.
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