PMID: 15218066

Prost AL, Bloc A, Hussy N, Derand R, Vivaudou M
Zinc is both an intracellular and extracellular regulator of KATP channel function.
J Physiol. 2004 Aug 15;559(Pt 1):157-67. Epub 2004 Jun 24., [PubMed]
Sentences
No. Mutations Sentence Comment
162 ABCC8 p.Lys719Met
X
ABCC8 p.Lys719Met 15218066:162:220
status: NEW
view ABCC8 p.Lys719Met details
 KATP channels with impaired nucleotide binding domains are still activated by intracellular Zn2+ Channel activity was measured at -30 mV in inside-out patches excised from Xenopus oocytes coinjected with Kir6.2 and SUR1(K719M,K1385M) or SUR2A(D832N,D1469N). Login to comment 163 ABCC8 p.Lys719Met
X
ABCC8 p.Lys719Met 15218066:163:41
status: NEW
view ABCC8 p.Lys719Met details
 A, activation by 20 µM Zn2+ of SUR1(K719M,K1385M)/Kir6.2 channels. B, average currents in 100 µM ATP measured before or during application of 20 µM Zn2+. Login to comment