PMID: 15076236

Savarino A, Lucia MB, Rastrelli E, Rutella S, Golotta C, Morra E, Tamburrini E, Perno CF, Boelaert JR, Sperber K, Cauda R
Anti-HIV effects of chloroquine: inhibition of viral particle glycosylation and synergism with protease inhibitors.
J Acquir Immune Defic Syndr. 2004 Mar 1;35(3):223-32., 2004-03-01 [PubMed]
Sentences
No. Mutations Sentence Comment
27 ABCC1 p.Val108Ile
X
ABCC1 p.Val108Ile 15076236:27:679
status: NEW
view ABCC1 p.Val108Ile details
 The laboratory-adapted HIV-1IIIB and HIV-2CBL/20 strains and the primary isolates HIV-1UG3 (clade A, R5) and HIV-1VI 829 (clade C, R5) from antiretroviral-naive African subjects were obtained as previously described.2,18 HIV-1PAVIA11 and HIV-1PAVIA12 (clade B, coreceptor usage undetermined) were isolated from Italian individuals with highly active antiretroviral therapy (HAART) failure and possess a genotypic profile of multidrug resistance.19 Protease resistance mutations were L10I, M46I, L63P, G73T, V77IV, I84V, and L90M in HIV-1PAVIA11 and L10I, M46L, I54V, L63V, A71T, V82A, and I93L in HIV-1PAVIA12, whereas RT resistance mutations were M41L, E44D, D67N, T69D, K103N, V108I, V118I, M184V, L210W, T215Y, F227FL, and K238KT in HIV-1PAVIA11 and M41L, E44D, D67N, M184V, L210W, and T215Y in HIV-1PAVIA12. Login to comment