PMID: 15039462

Bilan F, Thoreau V, Nacfer M, Derand R, Norez C, Cantereau A, Garcia M, Becq F, Kitzis A
Syntaxin 8 impairs trafficking of cystic fibrosis transmembrane conductance regulator (CFTR) and inhibits its channel activity.
J Cell Sci. 2004 Apr 15;117(Pt 10):1923-35. Epub 2004 Mar 23., 2004-04-15 [PubMed]
Sentences
No. Mutations Sentence Comment
188 ABCC7 p.Gly551Asp
X
ABCC7 p.Gly551Asp 15039462:188:117
status: NEW
view ABCC7 p.Gly551Asp details
 Moreover, we have observed, in COS-7 cells, that two cystic fibrosis widespread mutants, GFP-(F508del)CFTR and GFP- (G551D)CFTR, exhibited a pharmacological response and a trafficking consistent with the physiological data (data not shown). Login to comment