ABCMdb

PMID: 15001973

Giessmann T, Modess C, Hecker U, Zschiesche M, Dazert P, Kunert-Keil C, Warzok R, Engel G, Weitschies W, Cascorbi I, Kroemer HK, Siegmund W
CYP2D6 genotype and induction of intestinal drug transporters by rifampin predict presystemic clearance of carvedilol in healthy subjects.
Clin Pharmacol Ther. 2004 Mar;75(3):213-22., [PubMed]

Sentences

No. Mutations Sentence Comment

30 ABCB1 p.Gly1249Ala Genotyping of the MRP2 gene identified 9 subjects with CC and 3 with CT of the promoter variant C-24T, 7 subjects with GG and 5 with GA of G1249A, and 6 subjects with CC and 6 with CT of C3972T. Login to comment 58 ABCB1 p.Gly1249Ala ABCB1 p.Gly1249Ala CYP2D6 was genotyped for the major deficient alleles in white subjects, *3 (2549AϾdel frameshift mutation), *4 (1846GϾA splice-site mutation), *5 (gene deletion), and *6 (1707TϾdel frameshift mutation), as well as for gene duplications (*1xN, *2xN), and MDR1 was genotyped for G2677T/A and C3435T.19-21 MRP2 genotypes C-24T in the promoter region, G1249A in exon 10, and C3972T in exon 28 were determined by use of polymerase chain reaction-based restriction fragment length polymorphism assays by use of BbsI for distinction of C-24T and mismatch primers for G1249A and C3972T, introducing an AclI or BsrDI site in the presence of the mutation. Login to comment 94 ABCB1 p.Gly1249Ala The basal expression of P-gp and MRP2 (mRNA and protein levels) in our small number of subjects was not dependent on G2677T/A and C3435T of MDR1 and C-24T, G1249A, and C3972T of the MRP2 gene. Login to comment