ABCMdb

PMID: 14975760

Koike K, Deeley RG, Cole SP
Mapping of the MRPm5 epitope to the cytosolic region between transmembrane helices 13 and 14 in the drug and organic anion transporter, MRP1 (ABCC1).
Biochem Biophys Res Commun. 2004 Mar 12;315(3):719-25., [PubMed]

Sentences

No. Mutations Sentence Comment

79 ABCC1 p.Pro1060Ala Localization of the MAb MRPm5 epitope to CL6 between TM13 and TM14 During analysis of the functional consequences of mutating Pro residues in MSD3 (TM12-17) of MRP1, we observed that Ala substitution of Pro1060 and Pro1068 but not Pro1088 substantially diminished or eliminated the immunoreactivity of MRP1 with MAb MRPm5 (Fig. 1) [24]. Login to comment 99 ABCC1 p.Pro1068Ala Lack of reactivity of the P1068A MRP1 mutant with the MAb MRPm5 (Fig. 1B) indicates that Pro1068 is also an important component of the MRPm5 epitope. Login to comment