PMID: 14769732

Moss RB, Rodman D, Spencer LT, Aitken ML, Zeitlin PL, Waltz D, Milla C, Brody AS, Clancy JP, Ramsey B, Hamblett N, Heald AE
Repeated adeno-associated virus serotype 2 aerosol-mediated cystic fibrosis transmembrane regulator gene transfer to the lungs of patients with cystic fibrosis: a multicenter, double-blind, placebo-controlled trial.
Chest. 2004 Feb;125(2):509-21., [PubMed]
Sentences
No. Mutations Sentence Comment
147 ABCC7 p.Arg334Trp
X
ABCC7 p.Arg334Trp 14769732:147:212
status: NEW
view ABCC7 p.Arg334Trp details
 Seventy-seven percent of subjects randomized to placebo were homozygous for the ⌬F508 genotype compared to 25% of those randomized to tgAAVCF (p ϭ 0.01); however, all but one subject (homozygous for R334W, randomized to placebo) were pancreatic insufficient, and the age distribution, height, weight, sweat chloride test results, and baseline spirometric lung function were similar between the two groups. Login to comment