PMID: 14754409

Karwatsky JM, Georges E
Drug binding domains of MRP1 (ABCC1) as revealed by photoaffinity labeling.
Curr Med Chem Anticancer Agents. 2004 Jan;4(1):19-30., [PubMed]
Sentences
No. Mutations Sentence Comment
199 ABCC1 p.Arg1202Gly
X
ABCC1 p.Arg1202Gly 14754409:199:12
status: NEW
view ABCC1 p.Arg1202Gly details
 PAL of MRP1 R1202G was greatly reduced, although it retained transport activity and conferred vincristine resistance. Login to comment 233 ABCC1 p.Thr1242Ala
X
ABCC1 p.Thr1242Ala 14754409:233:14
status: NEW
view ABCC1 p.Thr1242Ala details
 A mutation of Thr1242 to Ala in MRP1 decreases photoaffinity labeling with [125 I]LY475776 and supports the possibility of a drug binding site in TM 17 of MRP1. Login to comment 234 ABCC1 p.Glu1089Gln
X
ABCC1 p.Glu1089Gln 14754409:234:127
status: NEW
view ABCC1 p.Glu1089Gln details
 Previous studies [67] showed that this residue is required for efficient transport of E217βG. In addition, a mutation of Glu1089 to Gln, the corresponding amino acid in mrp1, abolished MRP1-mediated anthracyclin resistance [68]. Login to comment 237 ABCC1 p.Glu1089Gln
X
ABCC1 p.Glu1089Gln 14754409:237:19
status: NEW
view ABCC1 p.Glu1089Gln details
 The extent of MRP1 Glu1089 to Gln photolabeling was reduced, whereas labeling of mrp1 Gln1089 to Glu was enhanced slightly. Login to comment