PMID: 14748729

Knight BL
ATP-binding cassette transporter A1: regulation of cholesterol efflux.
Biochem Soc Trans. 2004 Feb;32(Pt 1):124-7., [PubMed]
Sentences
No. Mutations Sentence Comment
64 ABCA1 p.Trp590Ser
X
ABCA1 p.Trp590Ser 14748729:64:52
status: NEW
view ABCA1 p.Trp590Ser details
 Furthermore, a specific mutation in the first loop (W590S) reduced efflux without affecting apoA1 binding, indicating that acceptor binding is necessary, but not sufficient, for cholesterol efflux. Login to comment 65 ABCA1 p.Trp590Ser
X
ABCA1 p.Trp590Ser 14748729:65:52
status: NEW
view ABCA1 p.Trp590Ser details
 Furthermore, a specific mutation in the first loop (W590S) reduced efflux without affecting apoA1 binding, indicating that acceptor binding is necessary, but not sufficient, for cholesterol efflux. Login to comment