ABCMdb

PMID: 14722086

Munehira Y, Ohnishi T, Kawamoto S, Furuya A, Shitara K, Imamura M, Yokota T, Takeda S, Amachi T, Matsuo M, Kioka N, Ueda K
Alpha1-syntrophin modulates turnover of ABCA1.
J Biol Chem. 2004 Apr 9;279(15):15091-5. Epub 2004 Jan 13., [PubMed]

Sentences

No. Mutations Sentence Comment

154 ABCA1 p.Trp590Ser A mutation of ABCA1 that causes Tangier disease (W590S) does not affect apoA-I binding or initial ATP binding/hydrolysis but results in a defect in lipid efflux (11, 31, 32). Login to comment 155 ABCA1 p.Trp590Ser ABCA1 p.Trp590Ser Because apoA-I failed to affect calpain degradation of ABCA1-W590S in HEK293 cells (10), additional signals following apoA-I binding to ABCA1 are speculated to be necessary for the subsequent inhibition of calpain degradation. Login to comment 156 ABCA1 p.Trp590Ser Because apoA-I failed to affect calpain degradation of ABCA1-W590S in HEK293 cells (10), additional signals following apoA-I binding to ABCA1 are speculated to be necessary for the subsequent inhibition of calpain degradation. Login to comment