PMID: 14715526

Clarke LL, Gawenis LR, Bradford EM, Judd LM, Boyle KT, Simpson JE, Shull GE, Tanabe H, Ouellette AJ, Franklin CL, Walker NM
Abnormal Paneth cell granule dissolution and compromised resistance to bacterial colonization in the intestine of CF mice.
Am J Physiol Gastrointest Liver Physiol. 2004 Jun;286(6):G1050-8. Epub 2004 Jan 8., [PubMed]
Sentences
No. Mutations Sentence Comment
25 ABCC7 p.Ser489*
X
ABCC7 p.Ser489* 14715526:25:151
status: NEW
view ABCC7 p.Ser489* details
 The obstructive syndrome and histopathological appearance are accurately reproduced in CF mouse models, in particular, CFTR knockout mice, such as the S489X mutant mouse (42). Login to comment 54 ABCC7 p.Ser489*
X
ABCC7 p.Ser489* 14715526:54:105
status: NEW
view ABCC7 p.Ser489* details
 The experiments in this study used gene-targeted weanling mice (4-6 wk old) that were homozygous for the S489X mutation (cftrtm1Unc ) (42) and maintained on a C57BL/6J background (Ͼ6 generations). Login to comment