ABCMdb

PMID: 14688046

Lee MK, Williams LE, Warnock DW, Arthington-Skaggs BA
Drug resistance genes and trailing growth in Candida albicans isolates.
J Antimicrob Chemother. 2004 Feb;53(2):217-24. Epub 2003 Dec 19., [PubMed]

Sentences

No. Mutations Sentence Comment

220 ABCB1 p.Arg467Lys Five of these, K143R, V404I, F449V, R467K and V509M, were found exclusively in non-trailing isolates with reduced fluconazole susceptibilities (isolates 8-12), andall were due tohomozygous nucleotide substitutions. Login to comment 221 ABCB1 p.Val437Ile Four homozygousnucleotide changes leading to aminoacidsubs- titutions E266D, V404I, V437I and V509M were found in the two Table 1. Login to comment 265 ABCB1 p.Arg467Lys ABCB1 p.Arg467Lys 1 2 3 4 5 6 7 8 9 10 11 12 Amino acid substitutiona Reference nucleotideb Nucleotide substitutionc F 105 F T T/C C T/C C T/C T/C D 116 E T T/A A T/A T/A T/A K 119 K A A/G G A/G A/G A/G K 128 T A A/C A/C S 137 S C C/T T C/T T T C/T C/T C/T K 143 R A G H 183 H T T/C C C C L 220 L C C/T T T T T C/T T T E 266 D A C A/C C L 320 L G A V 332 V T T/C C C C C L 340 L A A/G G A/G A/G G K 342 K A A/G G S 361 S A G G L 370 L C C/T T T T T T C/T T T T F 380 F T C C Y 401 Y T C C C C C V 404 I G A P 419 P T C C D 428 D T C C V 437 I G A A G 448 G G G/T A F 449 V T G V 452 V T C V 456 V T A R 467 K G A L 480 L A A/G G G G G G A/G G G N 490 N T T/C C C C C T/C C C V 509 M G A T229A, S279F, K287R, G307S, S405F, G448E, G448R, F449L, V452A, G464S, G465S, R467K and I471T.13,16,17,24 In this study, we found two of these mutations (K143R and R467K) in fluconazole-resistant C. albicans isolates derived from cases of oropharyngeal candidiasis (isolates 11 and 12). Login to comment