PMID: 14598019

Gerloff T
Impact of genetic polymorphisms in transmembrane carrier-systems on drug and xenobiotic distribution.
Naunyn Schmiedebergs Arch Pharmacol. 2004 Jan;369(1):69-77. Epub 2003 Nov 4., [PubMed]
Sentences
No. Mutations Sentence Comment
145 ABCB1 p.Gly1249Ala
X
ABCB1 p.Gly1249Ala 14598019:145:91
status: NEW
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 Frequently occurring SNPs were C24T (18.8%) of the promoter region and the two exonic SNPs G1249A (12.5%, exon 10) and C3972T (21.9%, exon 28). Login to comment 166 ABCC1 p.Arg433Ser
X
ABCC1 p.Arg433Ser 14598019:166:156
status: NEW
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 Digoxin plasma levels are inversely correlated with Pgp expression levels The functional relevance of the MRP1 SNPs G671 V, positioned within NBD1, and of Arg433Ser, located in a putative cytoplasmic loop, was tested using in vitro transport assays (Conrad et al. 2002). Login to comment 167 ABCC1 p.Arg433Ser
X
ABCC1 p.Arg433Ser 14598019:167:90
status: NEW
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 While the first did not change MRP1 transport activity for conjugated organic anions, the Arg433Ser polymorphism reduced transport activity of the substrates leucotriene C4 and estrone sulfate by half due to a decrease in Vmax for both compounds, whereas Km remained unchanged. Login to comment 168 ABCC1 p.Arg433Ser
X
ABCC1 p.Arg433Ser 14598019:168:71
status: NEW
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 In addition, doxorubicin-resistance of cells overexpressing the mutant Arg433Ser MRP1 was 2-fold higher compared to the wild-type. Login to comment