PMID: 14586389

Pauli-Magnus C, Feiner J, Brett C, Lin E, Kroetz DL
No effect of MDR1 C3435T variant on loperamide disposition and central nervous system effects.
Clin Pharmacol Ther. 2003 Nov;74(5):487-98., [PubMed]
Sentences
No. Mutations Sentence Comment
118 ABCB1 p.Asn21Asp
X
ABCB1 p.Asn21Asp 14586389:118:164
status: NEW
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 One individual was homozygous for MDR1*14, which contains the G2677T variation, leading to the Ser893 coding change plus an additional A61G variant resulting in an Asn21Asp change in P-glycoprotein. Login to comment 164 ABCC1 p.Ala893Ser
X
ABCC1 p.Ala893Ser 14586389:164:47
status: NEW
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 Importantly, the MDR1*13 haplotype encodes the Ala893Ser change in P-glycoprotein. Login to comment 168 ABCC1 p.Ala893Ser
X
ABCC1 p.Ala893Ser 14586389:168:231
status: NEW
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ABCC1 p.Ala893Thr
X
ABCC1 p.Ala893Thr 14586389:168:89
status: NEW
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ABCB1 p.Asn21Asp
X
ABCB1 p.Asn21Asp 14586389:168:103
status: NEW
view ABCB1 p.Asn21Asp details
 In the MDR1 3435CC group, 2 individuals had haplotypes encoding P-glycoprotein variants (Ala893Thr and Asn21Asp), and all subjects in the MDR1 3435TT group were at least heterozygous for a haplotype encoding for the P-glycoprotein Ala893Ser variant. Login to comment