ABCMdb

PMID: 14534403

Colombo JL
Long-acting bronchodilators in cystic fibrosis.
Curr Opin Pulm Med. 2003 Nov;9(6):504-8., [PubMed]

Sentences

No. Mutations Sentence Comment

110 ABCC7 p.Gly551Asp However, the study by Hordvik et al. [15•] attempted to look at this, and reported a trend in the direction of greater improvement with salmeterol in patients with so-called trafficking-competent mutations, such as G551D [15•]. Login to comment 112 ABCC7 p.Gly551Asp It should be noted, however, that other data suggest that CFTR protein with G551D does not respond to standard concentrations of forskolin or beta-agonists in vitro [19]. Login to comment 114 ABCC7 p.Thr164Ile CF patients with Gly16 allele or Thr164Ile genotypes had significantly worse lung function compared to those homozygous for the Arg16 allele. Login to comment