PMID: 12909621

Loo TW, Bartlett MC, Clarke DM
Simultaneous binding of two different drugs in the binding pocket of the human multidrug resistance P-glycoprotein.
J Biol Chem. 2003 Oct 10;278(41):39706-10. Epub 2003 Aug 7., 2003-10-10 [PubMed]
Sentences
No. Mutations Sentence Comment
116 ABCB1 p.Phe343Cys
X
ABCB1 p.Phe343Cys 12909621:116:83
status: NEW
view ABCB1 p.Phe343Cys details
 It appears that the presence of verapamil increased the reactivity or proximity of F343C to TMEA. Login to comment 137 ABCB1 p.Phe343Cys
X
ABCB1 p.Phe343Cys 12909621:137:7
status: NEW
view ABCB1 p.Phe343Cys details
 Mutant F343C was also treated with various concentrations of TMEA in the absence of verapamil (-Ver). Login to comment 180 ABCB1 p.Ile306Cys
X
ABCB1 p.Ile306Cys 12909621:180:8
status: NEW
view ABCB1 p.Ile306Cys details
 Residue I306C covalently binds to methanethiosulfonate-verapamil, and the P-gp ATPase activity is permanently activated. Login to comment