PMID: 12832418

Yang H, Shelat AA, Guy RK, Gopinath VS, Ma T, Du K, Lukacs GL, Taddei A, Folli C, Pedemonte N, Galietta LJ, Verkman AS
Nanomolar affinity small molecule correctors of defective Delta F508-CFTR chloride channel gating.
J Biol Chem. 2003 Sep 12;278(37):35079-85. Epub 2003 Jun 27., 2003-09-12 [PubMed]
Sentences
No. Mutations Sentence Comment
51 ABCC7 p.Gly551Asp
X
ABCC7 p.Gly551Asp 12832418:51:100
status: NEW
view ABCC7 p.Gly551Asp details
 Some measurements were done with stably transfected FRT cells expressing YFP-H148Q and wild-type or G551D-CFTR (18). Login to comment 134 ABCC7 p.Gly551Asp
X
ABCC7 p.Gly551Asp 12832418:134:100
status: NEW
view ABCC7 p.Gly551Asp details
 The six ⌬F508-CFTR potentiators shown in Fig. 3A were tested for activation of wild-type and G551D-CFTR in transfected FRT cells. Login to comment 135 ABCC7 p.Gly551Asp
X
ABCC7 p.Gly551Asp 12832418:135:38
status: NEW
view ABCC7 p.Gly551Asp details
 None of the compounds gave measurable G551D-CFTR activation at 10 ␮M in the presence of 20 ␮M FIG. 1. Login to comment 238 ABCC7 p.Gly551Asp
X
ABCC7 p.Gly551Asp 12832418:238:32
status: NEW
view ABCC7 p.Gly551Asp details
 None of the compounds activated G551D-CFTR even in the presence of a high concentration of a cAMP agonist nor did they cause endoplasmic reticulum-to-plasma membrane transport of ⌬F508-CFTR, as assessed functionally and biochemically. Login to comment