PMID: 12828958

Hanck C, Schneider A, Whitcomb DC
Genetic polymorphisms in alcoholic pancreatitis.
Best Pract Res Clin Gastroenterol. 2003 Aug;17(4):613-23., [PubMed]
Sentences
No. Mutations Sentence Comment
48 ABCC7 p.Arg117His
X
ABCC7 p.Arg117His 12828958:48:96
status: NEW
view ABCC7 p.Arg117His details
 Two missense mutations within the cationic trypsinogen gene, R122H and N29I (older nomenclature R117H and N21I) cause the majority of cases of HP.2022 Therefore, it had been hypothesized that an inappropriate activation of pancreatic zymogens (either by the prevention of trypsin inactivation, or by an enhanced activation of trypsinogen or by both mechanisms) might also play a role in alcoholic pancreatitis and that alcoholic pancreatitis might have the same genetic background as HP. Login to comment