ABCMdb

PMID: 12562963

Reimann F, Dabrowski M, Jones P, Gribble FM, Ashcroft FM
Analysis of the differential modulation of sulphonylurea block of beta-cell and cardiac ATP-sensitive K+ (K(ATP)) channels by Mg-nucleotides.
J Physiol. 2003 Feb 15;547(Pt 1):159-68. Epub 2003 Jan 10., [PubMed]

Sentences

No. Mutations Sentence Comment

124 ABCC8 p.Ser1237Tyr The binding sites for these drugs are not, however, believed to be identical, as the mutation S1237Y in SUR1 abolishes tolbutamide, but not meglitinide, inhibition (Ashfield et al. 1999). Login to comment 158 ABCC8 p.Ser1237Tyr The cytosolic loop linking TMs 15 and 16 has been shown to play a role in sulphonylurea binding to SUR1, as mutation of S1237Y abolished tolbutamide block and [3 H]glibenclamide binding, whilst inhibition by meglitinide(whichresemblesthenon-sulphonylureamoiety of glibenclamide) was unaffected (Ashfield et al. 1999). Login to comment