ABCMdb

PMID: 12556293

Bhandari A, Crawford SE, Huang L, Reenstra WW
Effects of oral genistein in mice.
Pediatr Pathol Mol Med. 2003 Mar-Apr;22(2):131-41., [PubMed]

Sentences

No. Mutations Sentence Comment

18 ABCC7 p.Gly551Asp Genistein also has been shown to potentiate PKA-dependent activation of the most common CFTR mutant DF508 and another common CF causing mutation G551D [3,6]. Login to comment 105 ABCC7 p.Gly551Asp A similar e¡ect hasbeen observed with G551D, another common CFmutationthat is more e/ciently targetedtothe plasma membrane [6]. Login to comment 106 ABCC7 p.Gly551Asp If similar e¡ects can be achieved in vivo, and with the proviso that DF508-CFTR and G551D-CFTR are present in the apical membrane, genistein could be of considerable therapeutic bene't to CF patients with these mutations. Login to comment 120 ABCC7 p.Gly551Asp However, since its utility as a treatment for CF would require continuous treatment, we chose to study the e¡ects of relatively long-term ad libitum consumption of genistein before assessing the ability of genistein to improve the morbidity and mortality of knockin mice with DF508- or G551D-CFTR. Login to comment