PMID: 12502786

Naren AP, Cobb B, Li C, Roy K, Nelson D, Heda GD, Liao J, Kirk KL, Sorscher EJ, Hanrahan J, Clancy JP
A macromolecular complex of beta 2 adrenergic receptor, CFTR, and ezrin/radixin/moesin-binding phosphoprotein 50 is regulated by PKA.
Proc Natl Acad Sci U S A. 2003 Jan 7;100(1):342-6. Epub 2002 Dec 26., 2003-01-07 [PubMed]
Sentences
No. Mutations Sentence Comment
198 ABCC7 p.Ser660Ala
X
ABCC7 p.Ser660Ala 12502786:198:39
status: NEW
view ABCC7 p.Ser660Ala details
 Deleting most of the R domain of CFTR (S660A ⌬RCFTR; lacking amino acids 708-835; ref. 32) abolished the PKA sensitivity of CFTR binding in the complex (Fig. 4 E and F). Login to comment