ABCMdb

PMID: 12426234

Devuyst O, Guggino WB
Chloride channels in the kidney: lessons learned from knockout animals.
Am J Physiol Renal Physiol. 2002 Dec;283(6):F1176-91., [PubMed]

Sentences

No. Mutations Sentence Comment

283 ABCC7 p.Gly551Asp In one additional model, the glycine at position 551 has been changed to an aspartate (G551D) (39). Login to comment 284 ABCC7 p.Gly551Asp ABCC7 p.Gly551Asp The G551D mutation is relatively common in patients with CF and results in a mutated CFTR protein that is processed normally but shows a significant reduction in cAMP-regulated Cl-channel activity (187). Login to comment 285 ABCC7 p.Gly551Asp The G551D mutation is relatively common in patients with CF and results in a mutated CFTR protein that is processed normally but shows a significant reduction in cAMP-regulated Cl- channel activity (187). Login to comment