PMID: 12403695

Aldallal N, McNaughton EE, Manzel LJ, Richards AM, Zabner J, Ferkol TW, Look DC
Inflammatory response in airway epithelial cells isolated from patients with cystic fibrosis.
Am J Respir Crit Care Med. 2002 Nov 1;166(9):1248-56., 2002-11-01 [PubMed]
Sentences
No. Mutations Sentence Comment
37 ABCC7 p.Trp1282*
X
ABCC7 p.Trp1282* 12403695:37:371
status: NEW
view ABCC7 p.Trp1282* details
 CF Cell Line without and with Integrated Complementation by Wild-Type CFTR METHODS Previous reports indicate that the IB3-1 CF airway epithelial cell line releases more IL-8 under basal conditions and in response toHuman Airway Epithelial Cells TNF-␣ and P. aeruginosa compared with matched wild-typeThe CF airway epithelial cell line IB3-1 (genotype ⌬F508/W1282X) CFTR-complemented cell lines (23, 47, 48). Login to comment 110 ABCC7 p.Trp1282*
X
ABCC7 p.Trp1282* 12403695:110:96
status: NEW
view ABCC7 p.Trp1282* details
 However, a significant decrease in IL-8 IB3-1 cells (that contain heterozygous ⌬F508 and W1282X secretion induced by IL-1beta treatment was observed in this cell CFTR mutant genes) and primary CF airway epithelial cells line after infection with adenovirus expressing either transgene. Login to comment