PMID: 12369997

Anthony V, Skach WR
Molecular mechanism of P-glycoprotein assembly into cellular membranes.
Curr Protein Pept Sci. 2002 Oct;3(5):485-501., [PubMed]
Sentences
No. Mutations Sentence Comment
307 ABCB1 p.Ser831Cys
X
ABCB1 p.Ser831Cys 12369997:307:83
status: NEW
view ABCB1 p.Ser831Cys details
 First, of the three cysteine substitutions made within the TM8-9 peptide loop only S831C, located two residues from the membrane boundary of TM8 was functional and thus available for topological analysis. Login to comment 310 ABCB1 p.Ser831Cys
X
ABCB1 p.Ser831Cys 12369997:310:43
status: NEW
view ABCB1 p.Ser831Cys details
 Thus it would not be surprising if residue S831C also remained unlabeled even if the TM8-9 loop were extracellular in a relatively small subset of P-gp molecules. Login to comment