ABCMdb

PMID: 12200052

Momburg F, Tan P
Tapasin-the keystone of the loading complex optimizing peptide binding by MHC class I molecules in the endoplasmic reticulum.
Mol Immunol. 2002 Oct;39(3-4):217-33., [PubMed]

Sentences

No. Mutations Sentence Comment

164 ABCB3 p.Leu410Phe Furthermore, the ER retention of hTpn-L410F was partially deficient, indicating that ER retention of Tpn is not a sole function of the canonical dilysine retention motif. Login to comment 165 ABCB3 p.Leu410Phe Furthermore, the ER retention of hTpn-L410F was partially deficient, indicating that ER retention of Tpn is not a sole function of the canonical dilysine retention motif. Login to comment 331 ABCB3 p.Leu410Phe A functional defect in the association of HC/beta2m-Crt-Tpn with TAP is given in the presence of soluble Tpn, Tpn-L410F, or mTpn molecules in .220 cells as described above (Lehner et al., 1998; Tan et al., 2002). Login to comment 332 ABCB3 p.Leu410Phe A functional defect in the association of HC/beta2m-Crt-Tpn with TAP is given in the presence of soluble Tpn, Tpn-L410F, or mTpn molecules in .220 cells as described above (Lehner et al., 1998; Tan et al., 2002). Login to comment 334 ABCB3 p.Leu410Phe We have recently shown that B*4402 molecules expressed in the presence of soluble hTpn, hTpn-L410F, or mTpn were suboptimally loaded with peptides (Tan et al., 2002). Login to comment 335 ABCB3 p.Leu410Phe We have recently shown that B*4402 molecules expressed in the presence of soluble hTpn, hTpn-L410F, or mTpn were suboptimally loaded with peptides (Tan et al., 2002). Login to comment