PMID: 12138119

Qian YM, Grant CE, Westlake CJ, Zhang DW, Lander PA, Shepard RL, Dantzig AH, Cole SP, Deeley RG
Photolabeling of human and murine multidrug resistance protein 1 with the high affinity inhibitor [125I]LY475776 and azidophenacyl-[35S]glutathione.
J Biol Chem. 2002 Sep 20;277(38):35225-31. Epub 2002 Jul 22., 2002-09-20 [PubMed]
Sentences
No. Mutations Sentence Comment
159 ABCC1 p.Glu1089Gln
X
ABCC1 p.Glu1089Gln 12138119:159:42
status: NEW
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ABCC11 p.Gln1086Glu
X
ABCC11 p.Gln1086Glu 12138119:159:155
status: NEW
view ABCC11 p.Gln1086Glu details
 The extent of [125 I]LY475776 labeling of E1089Q MRP1 was decreased severalfold relative to that of wild type protein, whereas [125 I]LY475776 labeling of Q1086E mrp1 was slightly enhanced when compared with wild type mrp1 (Fig. 6A, left panel). Login to comment 164 ABCC1 p.Thr1242Ala
X
ABCC1 p.Thr1242Ala 12138119:164:131
status: NEW
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 In contrast, when the same preparations of HEK membranes were photolabeled with azidophenacyl-[35 S]GSH, the extent of labeling of T1242A MRP1 was higher than that of the wild type protein. Login to comment 230 ABCC1 p.Thr1242Ala
X
ABCC1 p.Thr1242Ala 12138119:230:12
status: NEW
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 Mutation of Thr-1242 to Ala, as found at the corresponding position in murine mrp1, decreases the ability to transport E217betaG and to confer drug resistance, but does not affect LTC4 transport. Login to comment