ABCMdb

PMID: 12031979

Dabrowski M, Ashcroft FM, Ashfield R, Lebrun P, Pirotte B, Egebjerg J, Bondo Hansen J, Wahl P
The novel diazoxide analog 3-isopropylamino-7-methoxy-4H-1,2,4-benzothiadiazine 1,1-dioxide is a selective Kir6.2/SUR1 channel opener.
Diabetes. 2002 Jun;51(6):1896-906., [PubMed]

Sentences

No. Mutations Sentence Comment

154 ABCC8 p.Lys719Ala ABCC8 p.Lys719Ala ABCC8 p.Lys1384Met ABCC8 p.Lys1384Met Specifically, we mutated lysine 719 to alanine [SUR1(K719A)] and lysine 1384 to methionine [SUR1(K1384M)]. Login to comment 155 ABCC8 p.Lys719Ala ABCC8 p.Lys719Ala ABCC8 p.Lys1384Met ABCC8 p.Lys1384Met Specifically, we mutated lysine 719 to alanine [SUR1(K719A)] and lysine 1384 to methionine [SUR1(K1384M)]. Login to comment 161 ABCC8 p.Lys1384Met In this respect, NNC 55-9216 differs from diazoxide, which is still able to induce some activation of Kir6.2/SUR1(K1384M) currents (33). Login to comment 162 ABCC8 p.Lys1384Met In this respect, NNC 55-9216 differs from diazoxide, which is still able to induce some activation of Kir6.2/SUR1(K1384M) currents (33). Login to comment 230 ABCC8 p.Lys719Ala A: Macroscopic currents recorded from inside-out patches in response to a series of voltage ramps from -110 to 100 mV from oocytes coexpressing Kir6.2 and either SUR1(K719A) or SUR1(K1384 mol/l). Login to comment 231 ABCC8 p.Lys719Ala A: Macroscopic currents recorded from inside-out patches in response to a series of voltage ramps from d1a;110 to 100 mV from oocytes coexpressing Kir6.2 and either SUR1(K719A) or SUR1(K1384 mol/l). Login to comment