ABCMdb

PMID: 12023875

Gribble FM, Reimann F
Pharmacological modulation of K(ATP) channels.
Biochem Soc Trans. 2002 Apr;30(2):333-9., [PubMed]

Sentences

No. Mutations Sentence Comment

94 ABCC8 p.Ser1237Tyr However, the high-affinity blocking of Kir6.2/SURl channels by nateglinide and mitiglinide, which both show homology with meglitinide, has recently been reported to be abolished by the S1237Y mutation in SURl (see below), rather unexpectedly suggesting that their binding site overlaps with that of the sulphonylureas [37,38]. Login to comment 95 ABCC8 p.Ser1237Tyr However, the high-affinity blocking of Kir6.2/SURl channels by nateglinide and mitiglinide, which both show homology with meglitinide, has recently been reported to be abolished by the S1237Y mutation in SURl (see below), rather unexpectedly suggesting that their binding site overlaps with that of the sulphonylureas [37,38]. Login to comment