ABCMdb

PMID: 12019079

White TC, Holleman S, Dy F, Mirels LF, Stevens DA
Resistance mechanisms in clinical isolates of Candida albicans.
Antimicrob Agents Chemother. 2002 Jun;46(6):1704-13., [PubMed]

Sentences

No. Mutations Sentence Comment

211 ABCB1 p.Val437Ile Five mutations, located in the three hot spots, were observed in the three complete sequences; these mutations included D116E, K128T, K143R, E266D, and V437I (Table 2). Login to comment 214 ABCB1 p.Val437Ile Both of these mutations were also found in isolate 11 and were present in the first hot spot. Isolate 4 was heterozygous for D116E/D in the first hot spot, homozygous for E266D in the second hot spot, and heterozygous for V437I/V in the third hot spot. Login to comment 216 ABCB1 p.Val437Ile The V437I mutation was homozygous in isolates 5 and 22 (Table 2). Login to comment 218 ABCB1 p.Val437Ile Of these six mutations, the D116E, K128T, K143R, E266D, and V437I mutations have been described in isolates from other studies (18). Login to comment 239 ABCB1 p.Val437Ile Protein sequence alterations associated with resistancea Mutation Result for isolates whose complete gene was sequenced Result for isolates for which the hot spot III region was sequenced 4 7 11 3 5 8 9 22 D116E Heterozyg. Heterozyg. Homozyg. K128T WT Heterozyg. Homozyg. K143R WT WT Homozyg. E266D Homozyg. WT WT V437I Heterozyg. WT WT WT Homozyg. WT WT Homozyg. G448R WT WT WT WT WT Homozyg. WT WT a Point mutations that resulted in amino acid changes identified by sequencing of ERG11 from the indicated isolates. Login to comment