PMID: 11997458

Schroeder TH, Lee MM, Yacono PW, Cannon CL, Gerceker AA, Golan DE, Pier GB
CFTR is a pattern recognition molecule that extracts Pseudomonas aeruginosa LPS from the outer membrane into epithelial cells and activates NF-kappa B translocation.
Proc Natl Acad Sci U S A. 2002 May 14;99(10):6907-12. Epub 2002 May 7., 2002-05-14 [PubMed]
Sentences
No. Mutations Sentence Comment
20 ABCC7 p.Ser489*
X
ABCC7 p.Ser489* 11997458:20:71
status: NEW
view ABCC7 p.Ser489* details
 Noninbred, homozygous ⌬F508 cftr mice (5) and doubly transgenic S489X cftrFABPhuCFTR mice expressing no murine CFTR protein, but expressing wt human CFTR protein in the gastrointestinal tract from the CFTR gene under the control of the mouse fatty acid binding protein promoter (6), were bred in our facility (7). Login to comment 91 ABCC7 p.Ser489*
X
ABCC7 p.Ser489* 11997458:91:113
status: NEW
view ABCC7 p.Ser489* details
 There was no translocation of NF-␬B after intratracheal injection of P. aeruginosa into doubly transgenic S489X cftrFABPhuCFTR mice, which lacked expression of murine CFTR in any tissue but expressed human CFTR in the gastrointestinal tract (ref. Login to comment