ABCMdb

PMID: 11956513

Nakamura T, Sakaeda T, Horinouchi M, Tamura T, Aoyama N, Shirakawa T, Matsuo M, Kasuga M, Okumura K
Effect of the mutation (C3435T) at exon 26 of the MDR1 gene on expression level of MDR1 messenger ribonucleic acid in duodenal enterocytes of healthy Japanese subjects.
Clin Pharmacol Ther. 2002 Apr;71(4):297-303., [PubMed]

Sentences

No. Mutations Sentence Comment

81 ABCC1 p.Ala893Ser ABCC1 p.Ala893Thr The C3435T mutation is a silent mutation that does not cause amino acid substitution and is suggested to be linked with a mutation at exon 21, position 2677 [G2677(A,T)], producing Ala893Thr and Ala893Ser, respectively.6,11 The effect of the C3435T mutation may reflect that of G2677(A,T), and there may be racial differences in the relation between C3435T and G2677(A,T). Login to comment