ABCMdb

PMID: 11865092

Billion S, Tribout B, Cadet E, Queinnec C, Rochette J, Wheatley P, Bataille P
Hyperhomocysteinaemia, folate and vitamin B12 in unsupplemented haemodialysis patients: effect of oral therapy with folic acid and vitamin B12.
Nephrol Dial Transplant. 2002 Mar;17(3):455-61., [PubMed]

Sentences

No. Mutations Sentence Comment

1 ABCC8 p.Cys677Thr Hyperhomocysteinaemia, a risk factor for atherosclerosis, is common in dialysis patients and particularly in those homozygous for a common polymorphism in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene (C677T transition). Login to comment 4 ABCC8 p.Cys677Thr The responses were analysed for the C677T genotypes of MTHFR. Login to comment 6 ABCC8 p.Cys677Thr Plasma tHcy, folate and vitamin B12 were measured in 51 haemodialysis patients genotyped for the C677T MTHFR mutation (homozygotes, TT; heterozygotes, CT; without mutation, CC). Login to comment 19 ABCC8 p.Cys677Thr (ii) After folate therapy, tHcy levels decreased significantly in all patients and were identical between the three C677T MTHFR genotype subgroups. Login to comment 69 ABCC8 p.Cys677Thr The C677T polymorphic site was determined by PCR amplification followed by restriction-enzyme digestion of the products and analysed on 2% agarose gels w13x. Login to comment 75 ABCC8 p.Cys677Thr Results Table 1 shows the genotypic distribution of the (C677T) MTHFR mutation and the main characteristics of patients in the different genotype groups. Login to comment