ABCMdb

PMID: 11823531

Tan P, Kropshofer H, Mandelboim O, Bulbuc N, Hammerling GJ, Momburg F
Recruitment of MHC class I molecules by tapasin into the transporter associated with antigen processing-associated complex is essential for optimal peptide loading.
J Immunol. 2002 Feb 15;168(4):1950-60., [PubMed]

Sentences

No. Mutations Sentence Comment

287 ABCB3 p.Leu410Phe The novel TM point mutant L410F has essentially lost the capacity of wild-type Tpn to elevate TAP1 steady state levels. Login to comment 289 ABCB3 p.Leu410Phe The partial suspension of ER retention of the L410F mutant may have contributed to the failing stabilization of TAP. Login to comment 290 ABCB3 p.Leu410Phe ABCB3 p.Leu410Phe The formation of complexes between Crt, hTpn-L410F, and HC (Fig. 5A) suggests, however, that the TM mutation did not significantly affect the interaction of Tpn with HC. Login to comment 292 ABCB3 p.Leu410Phe The partial suspension of ER retention of the L410F mutant may have contributed to the failing stabilization of TAP. Login to comment 293 ABCB3 p.Leu410Phe The formation of complexes between Crt, hTpn-L410F, and HC (Fig. 5A) suggests, however, that the TM mutation did not significantly affect the interaction of Tpn with HC. Login to comment 327 ABCB3 p.Leu410Phe In accordance with recent studies by the McCluskey group, who analyzed Kb - and B*2705-associated peptide spectra in the presence and absence of Tpn (12, 36), we noted a considerable overlap in the spectra derived from .220.B*4402 cells transfected with hTpn, mTpn, or hTpn-L410F. Login to comment 330 ABCB3 p.Leu410Phe In accordance with recent studies by the McCluskey group, who analyzed Kb - and B*2705-associated peptide spectra in the presence and absence of Tpn (12, 36), we noted a considerable overlap in the spectra derived from .220.B*4402 cells transfected with hTpn, mTpn, or hTpn-L410F. Login to comment