PMID: 11717455

Poschet JF, Boucher JC, Tatterson L, Skidmore J, Van Dyke RW, Deretic V
Molecular basis for defective glycosylation and Pseudomonas pathogenesis in cystic fibrosis lung.
Proc Natl Acad Sci U S A. 2001 Nov 20;98(24):13972-7., 2001-11-20 [PubMed]
Sentences
No. Mutations Sentence Comment
107 ABCC7 p.Trp1282*
X
ABCC7 p.Trp1282* 11717455:107:476
status: NEW
view ABCC7 p.Trp1282* details
 Hyperacidification of TGN in CF Cell line TGN pH IB3-1 (mutant) 6.0 Ϯ 0.1 (n ϭ 17)* C38 (corrected) 6.6 Ϯ 0.1 (n ϭ 18) S9 (corrected) 6.7 Ϯ 0.1 (n ϭ 24) CFT1 (mutant) 6.2 Ϯ 0.1 (n ϭ 10)* CFT1-LCFSN (corrected) 6.7 Ϯ 0.1 (n ϭ 9) CFT1-LC3 (mutant) 6.3 Ϯ 0.1 (n ϭ 10) CFT1-⌬F508 (mutant) 6.2 Ϯ 0.1 (n ϭ 19) IB3-1 is a human bronchial cell line derived from a patient with a ⌬F508/ W1282X CFTR (25). Login to comment