PMID: 11598005

Rosenberg MF, Velarde G, Ford RC, Martin C, Berridge G, Kerr ID, Callaghan R, Schmidlin A, Wooding C, Linton KJ, Higgins CF
Repacking of the transmembrane domains of P-glycoprotein during the transport ATPase cycle.
EMBO J. 2001 Oct 15;20(20):5615-25., 2001-10-15 [PubMed]
Sentences
No. Mutations Sentence Comment
136 ABCB1 p.Leu339Cys
X
ABCB1 p.Leu339Cys 11598005:136:135
status: NEW
view ABCB1 p.Leu339Cys details
 The mutant proteins were active, with a drug-stimulated ATPase activity comparable to that of cysteine-less P-gp (except for L329C and L339C, which were discounted) (data not shown). Login to comment 138 ABCB1 p.Gly324Cys
X
ABCB1 p.Gly324Cys 11598005:138:90
status: NEW
view ABCB1 p.Gly324Cys details
 As expected, the drug-stimulated ATPase activities of cysteine-less P-gp and the control (G324C, which has a single cysteine in an extracellular loop; Blott et al., 1999) were not signi®cantly affected by either reagent. Login to comment