PMID: 11560923

Weixel KM, Bradbury NA
Mu 2 binding directs the cystic fibrosis transmembrane conductance regulator to the clathrin-mediated endocytic pathway.
J Biol Chem. 2001 Dec 7;276(49):46251-9. Epub 2001 Sep 17., 2001-12-07 [PubMed]
Sentences
No. Mutations Sentence Comment
155 ABCC7 p.Tyr1424Ala
X
ABCC7 p.Tyr1424Ala 11560923:155:33
status: NEW
view ABCC7 p.Tyr1424Ala details
 Furthermore, peptides containing alanine substitution at tyrosine 1424 and isoleucine 1427, *ADSA, abolished the ability of the peptide to cross-link to AP-2 (Fig. 2A, lane 3). Login to comment 331 ABCC7 p.Tyr1424Ala
X
ABCC7 p.Tyr1424Ala 11560923:331:84
status: NEW
view ABCC7 p.Tyr1424Ala details
 These results strongly correlate with the reduction in endocytosis observed in CFTR Y1424A mutants (10, 35), suggesting that the interaction specifically affected is that between ␮2 and the 1424 YDSI endocytosis signal. Login to comment 339 ABCC7 p.Tyr1424Ala
X
ABCC7 p.Tyr1424Ala 11560923:339:134
status: NEW
view ABCC7 p.Tyr1424Ala details
 Moreover, the only mutation identified that affected CFTR internalization was the YXX⌽ motif in the carboxyl terminus of CFTR, Y1424A. Login to comment