PMID: 11478590

Linsdell P
Thiocyanate as a probe of the cystic fibrosis transmembrane conductance regulator chloride channel pore.
Can J Physiol Pharmacol. 2001 Jul;79(7):573-9., [PubMed]
Sentences
No. Mutations Sentence Comment
131 ABCC7 p.Thr338Ala
X
ABCC7 p.Thr338Ala 11478590:131:190
status: NEW
view ABCC7 p.Thr338Ala details
ABCC7 p.Phe337Ser
X
ABCC7 p.Phe337Ser 11478590:131:183
status: NEW
view ABCC7 p.Phe337Ser details
 In spite of this caveat, it is interesting to note that the effects of mutations within the pore that drastically alter SCN- permeability but have only small effects on SCN- binding (F337S, T338A; Linsdell 2001) may result in such a model from alterations in barrier height, implying that the effects of these mutations may result primarily from changes in anion access to the pore. Login to comment