ABCMdb

PMID: 11455011

Song J, Melera PW
Transmembrane domain (TM) 9 represents a novel site in P-glycoprotein that affects drug resistance and cooperates with TM6 to mediate [125I]iodoarylazidoprazosin labeling.
Mol Pharmacol. 2001 Aug;60(2):254-61., [PubMed]

Sentences

No. Mutations Sentence Comment

172 ABCB1 p.Gly185Val A similar argument has been proposed (Loo and Clark, 1999) to explain how the G185V mutation in MDR1, which also lies outside of the proposed drug binding pocket, alters the cross-resistance phenotype compared with the wild-type (Choi et al., 1989). Login to comment 183 ABCB1 p.Gly185Val Unlike the G185V mutation, whose pleiotropic effects on MDR1 function (Ramachandra et al., 1996) were interpreted to be caused by higher order structural perturbations, the TM9 mutations displayed no such effects on Pgp1 function. Login to comment