PMID: 11404244

Rubenstein RC, Lyons BM
Sodium 4-phenylbutyrate downregulates HSC70 expression by facilitating mRNA degradation.
Am J Physiol Lung Cell Mol Physiol. 2001 Jul;281(1):L43-51., [PubMed]
Sentences
No. Mutations Sentence Comment
136 ABCC7 p.Trp1282*
X
ABCC7 p.Trp1282* 11404244:136:128
status: NEW
view ABCC7 p.Trp1282* details
 Our laboratory has previously demonstrated in the immortalized CF bronchiolar epithelial cell line IB3-1 (genotype ⌬F508/W1282X) LPHENYLBUTYRATE FACILITATES HSC70 MRNA DEGRADATION (33) that 4PBA results in an ϳ40-50% reduction in steady-state expression of HSC70 mRNA and protein (25) and improved ⌬F508 CFTR intracellular trafficking (23). Login to comment