PMID: 11356825

Urbatsch IL, Gimi K, Wilke-Mounts S, Lerner-Marmarosh N, Rousseau ME, Gros P, Senior AE
Cysteines 431 and 1074 are responsible for inhibitory disulfide cross-linking between the two nucleotide-binding sites in human P-glycoprotein.
J Biol Chem. 2001 Jul 20;276(29):26980-7. Epub 2001 May 16., 2001-07-20 [PubMed]
Sentences
No. Mutations Sentence Comment
299 ABCB1 p.Leu439Cys
X
ABCB1 p.Leu439Cys 11356825:299:215
status: NEW
view ABCB1 p.Leu439Cys details
 In a previous report (42), inhibitory disulfide cross-linking was detected between the natural Cys-1074 residue in NBS2 of human Pgp and the engineered mutant residues Cys-427 (mutation G427C) and Cys-439 (mutation L439C) in NBS1. Login to comment 301 ABCB1 p.Leu439Cys
X
ABCB1 p.Leu439Cys 11356825:301:215
status: NEW
view ABCB1 p.Leu439Cys details
 In a previous report (42), inhibitory disulfide cross-linking was detected between the natural Cys-1074 residue in NBS2 of human Pgp and the engineered mutant residues Cys-427 (mutation G427C) and Cys-439 (mutation L439C) in NBS1. Login to comment