ABCMdb

PMID: 11350833

Mhanna MJ, Ferkol T, Martin RJ, Dreshaj IA, van Heeckeren AM, Kelley TJ, Haxhiu MA
Nitric oxide deficiency contributes to impairment of airway relaxation in cystic fibrosis mice.
Am J Respir Cell Mol Biol. 2001 May;24(5):621-6., [PubMed]

Sentences

No. Mutations Sentence Comment

23 ABCC7 p.Ser489* To test this hypothesis, we compared the airway relaxant response of CF mice homozygous for the null S489X mutation with that of their normal littermates. Login to comment 28 ABCC7 p.Ser489* Materials and Methods Animals Male and female mice homozygous for the S489X (CFTR-/- ) mutation of the CFTR and their normal littermates (CFTRϩ/ϩ ) were studied (18, 19). Login to comment 35 ABCC7 p.Ser489* of Pediatrics, Washington University School of Medicine, St. Louis, MO. Abbreviations: analysis of variance, ANOVA; cystic fibrosis, CF; CF transmembrane conductance regulator, CFTR; mice homozygous for the S489X mutation of the CFTR, CFTR-/- mice; normal littermates of CFTR-/- mice, CFTRϩ/ϩ mice; electrical field stimulation, EFS; inducible NOS, iNOS; NG-nitro-L-arginine methylester, L-NAME; neuronal NOS, nNOS; nitric oxide, NO; NO synthase, NOS; prostaglandin, PG; standard error of the mean, SEM; substance P, SP; percentage of maximal tracheal tension, %T max. Login to comment