ABCMdb

PMID: 11334731

Liang Y, Meleady P, Cleary I, McDonnell S, Connolly L, Clynes M
Selection with melphalan or paclitaxel (Taxol) yields variants with different patterns of multidrug resistance, integrin expression and in vitro invasiveness.
Eur J Cancer. 2001 May;37(8):1041-52., [PubMed]

Sentences

No. Mutations Sentence Comment

135 ABCC2 p.Leu23Arg Circumvention studies with verapamil and cyclosporin A The Pgp-overexpressing cell line DLKP-A and MRP1-overexpressing cell line COR-L23R were used as Fig. 1. Login to comment 136 ABCC2 p.Leu23Arg Circumvention studies with verapamil and cyclosporin A The Pgp-overexpressing cell line DLKP-A and MRP1-overexpressing cell line COR-L23R were used as Fig. 1. Login to comment 152 ABCC2 p.Leu23Arg Table 3 Circumvention studies with verapamil and cyclosporin A in the RPMI-2650 cell line and its taxol- and melphalan-resistant variantsa Cell line IC50 (nM) ADR ADR+ verapamil (1 mg/ml) ADR+ cyclosporin A (1 mg/ml) COR-L23R 2097Æ364 938Æ146 1435Æ129 DLKP-A 5750Æ275 441Æ157 1582Æ167 RPMI-2650 110Æ37 59Æ18 77Æ19 RPMI-2650Tx 5750Æ224 2171Æ195 497Æ118 RPMI-2650Ml 690Æ138 48Æ15 304Æ125 ADR, doxorubicin. Login to comment 153 ABCC2 p.Leu23Arg Table 3 Circumvention studies with verapamil and cyclosporin A in the RPMI-2650 cell line and its taxol- and melphalan-resistant variantsa Cell line IC50 (nM) ADR ADR+ verapamil (1 mg/ml) ADR+ cyclosporin A (1 mg/ml) COR-L23R 2097364 938146 1435129 DLKP-A 5750275 441157 1582167 RPMI-2650 11037 5918 7719 RPMI-2650Tx 5750224 2171195 497118 RPMI-2650Ml 690138 4815 304125 ADR, doxorubicin. Login to comment