ABCMdb

PMID: 11284688

Druley TE, Stein WD, Ruth A, Roninson IB
P-glycoprotein-mediated colchicine resistance in different cell lines correlates with the effects of colchicine on P-glycoprotein conformation.
Biochemistry. 2001 Apr 10;40(14):4323-31., [PubMed]

Sentences

No. Mutations Sentence Comment

38 ABCB1 p.Lys1076Met ABCB1 p.Lys433Met The MK, KM, and MM mutants contain amino acid substitutions at either one (KM or MK) or both (MM) conserved lysine residues in the Walker A motifs of the N-terminal or C-terminal NBS, K433M and K1076M, respectively. Login to comment 135 ABCB1 p.Lys1076Met ABCB1 p.Lys433Met Figure 4B compares the effects of increasing concentrations of colchicine on UIC2 reactivity of LMtk- cell lines transfected with either the wild-type human Pgp (KK-H) or Pgp mutants carrying K433M or K1076M substitutions of the essential lysine residues in the Walker A motifs of the N-terminal (MK-H) or C-terminal (KM-H) NBS, respectively. Login to comment