PMID: 11284687

Druley TE, Stein WD, Roninson IB
Analysis of MDR1 P-glycoprotein conformational changes in permeabilized cells using differential immunoreactivity.
Biochemistry. 2001 Apr 10;40(14):4312-22., [PubMed]
Sentences
No. Mutations Sentence Comment
49 ABCB1 p.Lys1076Met
X
ABCB1 p.Lys1076Met 11284687:49:269
status: NEW
view ABCB1 p.Lys1076Met details
ABCB1 p.Lys433Met
X
ABCB1 p.Lys433Met 11284687:49:259
status: NEW
view ABCB1 p.Lys433Met details
 Site-directed mutagenesis was used to generate the MK, KM, and MM mutants, which contain amino acid substitutions at either one (KM or MK) or both (MM) conserved lysine residues in the Walker A motifs of the N-terminal or C-terminal nucleotide-binding sites, K433M and K1076M, respectively. Login to comment