ABCMdb

PMID: 11161838

Mailleau C, Paul A, Colin M, Xing PX, Guernier C, Bernaudin JF, Capeau J, Brahimi-Horn MC
Glycoconjugate metabolism in a cystic fibrosis knockout mouse model.
Mol Genet Metab. 2001 Feb;72(2):122-31., [PubMed]

Sentences

No. Mutations Sentence Comment

22 ABCC7 p.Ser489* The cftr gene was inactivated by introduction of an in-frame stop codon (the allele S489X) resulting in a truncated gene product. Login to comment 34 ABCC7 p.Ser489* ABCC7 p.Ser489* Female and male 129/BC mice heterozygous for the S489X mutation were crossed to obtain homozygous S489X mice (12). Login to comment 42 ABCC7 p.Ser489* ABCC7 p.Ser489* For the purposes of this study wild-type mice were classified as cftraf9;/af9; , mice heterozygous for the S489X mutation as cftraf9;/afa; , and mice homozygous for the S489X mutation as cftrafa;/afa; . Login to comment